Protein kinase C activators inhibit the antigen receptor‐coupled polyphosphoinositide phosphodiesterase in murine B lymphocytes

FEBS Letters

Harnett, M.M.¹  Klaus, G.G.B.¹ 

[1] Division of Immunology, National Institute for Medical Research, London NW7 1AA, England

关键词: Antigen receptor;    Phorbol ester;    Inositol phosphate;    Negative feedback inhibition;    Polyphosphoinositide phosphodiesterase inhibition;    (Murine B lymphocyte);    anti-Ig;    anti-immunoglobulin antibodies;    DAG;    1;    2-diacylglycerol;    GTPγS;    guanosine-5′-O-(3-thiotriphosphate);    IP3;    inositol trisphosphate;    PIP2;    phosphatidylinositol 4;    5-bisphosphate;    PKC;    protein kinase C;    PMA;    phorbol 12-myristate 13-acetate;    PPI-PDE;    polyphosphoinositide phosphodiesterase;   

DOI  :  10.1016/0014-5793(88)80934-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein kinase C activators (e.g. PMA) inhibit the inositol phosphate release generated by crosslinking antigen receptors (sIgM and sIgD) on murine B lymphocytes with anti-receptor antibodies. Unlike other Ca²⁺-mobilizing receptor systems, the antigen receptor signal transduction pathway in B cells is not interrupted by PMA at the level of receptor/G-protein or G-protein/polyphosphoinositide phosphodiesterase coupling. In these cells, PMA, presumably by activating protein kinase C, inhibits inositol phosphate release by direct effects on the polyphosphoinositide-specific phosphodiesterase.

【 授权许可】

Unknown