期刊论文详细信息
FEBS Letters | |
Expression and electrophysiological identification of the receptor for bombesin and gastrin‐releasing peptide in Xenopus laevis oocytes injected with polyA+ RNA from rat brain | |
Morley, Steven D.1  Meyerhof, Wolfgang1  Richter, Dietmar1  | |
[1] Institut für Zellbiochemie und klinische Neurobiologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 2000 Hamburg 20, FRG | |
关键词: Bombesin receptor; Gastrin-releasing peptide receptor; Thyrotropin-releasing hormone receptor; Serotonin receptor; mRNA; Microinjection; Voltage-clamped oocyte; (Rat brain); | |
DOI : 10.1016/0014-5793(88)80555-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The receptor for bombesin and the related peptide, gastrin-releasing peptide (GRP) has been induced in frog oocytes by injection of polyA+ RNA from rat brain. The primed oocytes responded to peptides of the bombesin family (GRP, neuromedin C of bombesin) by showing dose-dependent oscillations in membrane currents as recorded by the voltage-clamp method. The induced membrane changes were suppressed when oocytes were pretreated with a bombesin-receptor antagonist.
【 授权许可】
Unknown
【 预 览 】
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