Botulinum toxin‐induced ADP‐ribosylation and inhibition of exocytosis are unrelated events

FEBS Letters

Adam-Vizi, V.²  Rosener, S.¹  Knight, D.E.²  Aktories, K.¹ 

[1] Rudolf-Buchheim-Institut für Pharmacologie, Justus-Liebig-Universitat, D-6300 Gießen, FRG;MRC Secretory Mechanisms Group, Division of Biomedical Sciences, King's College, London WC2R 2LS, England

关键词: Botulinum toxin;    ADP-ribosylation;    Exocytosis;    Catecholamine;    (Adrenal medulla);   

DOI  :  10.1016/0014-5793(88)80496-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hypothesis that inhibition of secretion by botulinum neurotoxin type D occurs by an intracellular process involving ADP-ribosylation has been directly tested by measuring both the extent of inhibition of secretion and of ADP-ribosylation in the same cells. Although the inhibitory effect of unpurified toxin closely parallels intracellular ribosylation, the two events are clearly unrelated, as using purified D and C3 toxins together with their antibodies, each of these events can be either stimulated or inhibited independently of each other.

【 授权许可】

Unknown