期刊论文详细信息
FEBS Letters | |
Botulinum toxin‐induced ADP‐ribosylation and inhibition of exocytosis are unrelated events | |
Adam-Vizi, V.2  Rosener, S.1  Knight, D.E.2  Aktories, K.1  | |
[1] Rudolf-Buchheim-Institut für Pharmacologie, Justus-Liebig-Universitat, D-6300 Gießen, FRG;MRC Secretory Mechanisms Group, Division of Biomedical Sciences, King's College, London WC2R 2LS, England | |
关键词: Botulinum toxin; ADP-ribosylation; Exocytosis; Catecholamine; (Adrenal medulla); | |
DOI : 10.1016/0014-5793(88)80496-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The hypothesis that inhibition of secretion by botulinum neurotoxin type D occurs by an intracellular process involving ADP-ribosylation has been directly tested by measuring both the extent of inhibition of secretion and of ADP-ribosylation in the same cells. Although the inhibitory effect of unpurified toxin closely parallels intracellular ribosylation, the two events are clearly unrelated, as using purified D and C3 toxins together with their antibodies, each of these events can be either stimulated or inhibited independently of each other.
【 授权许可】
Unknown
【 预 览 】
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