The ‘cation‐dependent’ mannose 6‐phosphate receptor binds ligands in the absence of divalent cations

FEBS Letters

von Figura, Kurt¹  Junghans, Ulrich¹  Waheed, Abdul¹ 

[1] Universität Göttingen, Zentrun Biochemie, Abt. Biochemie II, Gosslerstr. 12d, D 3400 Göttingen, FRG

关键词: Lysosomal enzyme;    Enzyme receptor;    Mannose 6-phosphate receptor;   

DOI  :  10.1016/0014-5793(88)80176-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The requirement of divalent cations for binding of the 46 kDa mannose 6-phosphate receptors to phosphomannan and pentamannose 6-phosphate-substituted bovine serum albumin was examined. Receptors from human liver and human brain bound to both affinity ligands in the absence or presence of divalent cations with similar efficiency. The requirement for divalent cations therefore appears not to be necessary for the binding.

【 授权许可】

Unknown