Antibodies against the cytoplasmic tail can differentiate between the quaternary forms of the M r 46000 mannose 6‐phosphate receptor

FEBS Letters

von Figura, Kurt¹  Nadimpalli, Siva Kumar¹  Schmidt, Bernhard¹  Hille, Annette¹ 

[1] Georg-August-Universität, Abt. Biochemie, Gosslerstr. 12d, D-3400 Göttingen, Germany

关键词: Mannose 6-phosphate receptor;    Peptide-specific antibody;    Quaternary structure;    Receptor recycling;    Transport signal;    MPR 46;    M r 46 000 mannose 6-phosphate receptor;    PAGE;    polyacrylamide gel electrophoresis;    SDS;    sodium dodecyl sulfate;   

DOI  :  10.1016/0014-5793(91)80204-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An antiserum against a peptide of the cytoplasmic tail of the M _r 46000 mannose 6-phosphate receptor is described which recognizes preferentially the tetrameric versus the dimeric form of this receptor. This indicates that the conformation of the cytoplasmic tail, which harbours signals necessary for the trafficking of the receptor, depends on the quaternary structure of the receptor.

【 授权许可】

Unknown