Effects of long‐chain N‐acylethanolamines on lipid peroxidation in cardiac mitochondria

FEBS Letters

Schmid, H.H.O.¹  Parinandi, N.L.¹ 

[1] The Hormel Institute, University of Minnesota, Austin, MN 55912, USA

关键词: N-Oleoyl-2-aminoethanol;    Oxygen free radical;    (Cardiac mitochondria);    MDA;    malondialdehyde;    TBA;    thiobarbituric acid;    NOE;    N-oleoyl-2-aminoethanol;    NOP;    N-oleoyl-3-aminopropanol;    NOPD;    N-oleoyl-3-aminopropane-1;    2-diol;   

DOI  :  10.1016/0014-5793(88)80169-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A long-chain N-acylethanolamine (N-oleoyl-2-aminoethanol) is shown to inhibit the production of thiobarbituric acid-reactive substances in rat heart mitochondria treated with Fe²⁺ or Fe³⁺/ADP. The inhibition is concentration-dependent in the range 50–150 μM of the agent and can be nearly complete depending on the type and amount of the free radical-generating system. Structural analogues of N-acylethanolamine are inhibitory as well, but neither oleic acid nor ethanolamine has measurable effects. N-Oleoyl-2-aminoethanol affects peroxidation of linoleic acid micelles only minimally and has no effect on deoxyribose peroxidation.

【 授权许可】

Unknown