Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP

FEBS Letters

Mamikonova, Tatyana A.¹  Tsofina, Lilia M.¹  Myakotina, Olga L.¹  Minina, Svetlana V.¹  Shklovskl-Kordi, Nikita E.¹  Liberman, Efim A.¹ 

[1] Institute for Information Transmission Problems, Acad. Sci. USSR, Ermolova str., 19, Moscow, 101447, USSR

关键词: cyclic AMP;    Neuron permeability;    Protein kinase;    Glycolysis;    Oxidative phosphorylation;    (Helix lucorum);   

DOI  :  10.1016/0014-5793(88)80074-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Influence of different metabolic poisons on cAMP-evoked neuron membrane permeability is investigated. Drugs preventing cAMP binding with R subunits of protein kinase decrease the cAMP-evoked current, but the inhibitor of the C subunit, H8, has no effect. The cAMP-dependent current is increased by uncouplers and decreased by inhibitors of glycolysis and oxidative phosphorylation. The mechanism of cAMP action on neuron permeability is discussed.

【 授权许可】

Unknown