Calcium channel blockers inhibit bacterial chemotaxis

FEBS Letters

Hirata, Hajime²  Kusaka, Iwao¹  Matsushita, Taku¹ 

[1] Institute of Applied Microbiology, University of Tokyo, Bunkyo-ku, Yayoi 1-1-1, Tokyo 113, Japan;Department Of Biochemistry, Jichi Medical School, Tochigi 329-04, Japan

关键词: Ca2+ channel blocker;    ω-Conotoxin;    Chemotaxis;    Ca2+;    (Bacillus subtilis);   

DOI  :  10.1016/0014-5793(88)80072-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of several Ca²⁺ channel blockers, which inhibit the voltage-dependent Ca²⁺ uptake in Bacillus subtilis, on chemotactic behaviour of the bacterium was studied. Nitrendipine, verapamil, LACl₃ and ω-conotoxin were tested and these blockers inhibited chemotactic behaviour in the bacterium toward L-alanine. Among these blockers, ω-conotoxin was the most effective inhibitor of chemotaxis. EGTA was also as effective as ω-conotoxin. In contrast, these blockers, did not inhibit the motility and the growth of the bacterium. These results suggest that internal Ca²⁺ plays an important role in the sensory system of bacterial chemotaxis.

【 授权许可】

Unknown