Effects of β-Blockers and Nicardipine on Oxotremorine-Induced Tremor in Common Marmosets

The Japanese Journal of Pharmacology

Minoru Mitsuda¹  Masahiro Nomoto¹  Shin-ichi Iwata¹ 

[1] Department of Pharmacology, Faculty of Medicine, Kagoshima University

关键词: Oxotremorine-induced tremor;    β-Blocker;    Ca2+ channel blocker;   

DOI  :  10.1254/jjp.81.244

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Effects of β-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as “points”, which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. β-Blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor.

【 授权许可】

Unknown