The Japanese Journal of Pharmacology | |
Effects of β-Blockers and Nicardipine on Oxotremorine-Induced Tremor in Common Marmosets | |
Minoru Mitsuda1  Masahiro Nomoto1  Shin-ichi Iwata1  | |
[1] Department of Pharmacology, Faculty of Medicine, Kagoshima University | |
关键词: Oxotremorine-induced tremor; β-Blocker; Ca2+ channel blocker; | |
DOI : 10.1254/jjp.81.244 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(15)Effects of β-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as “points”, which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. β-Blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912080714576ZK.pdf | 438KB | download |