Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells

FEBS Letters

Hansen, A.B.¹  Rosselin, G.E.²  Gespach, C.P.²  Holst, J.J.¹ 

[1] Institute of Medical Physiology C, The Panum Institute, Blegdamsvej 3c, DK-2200 Copenhagen N, Denmark;Unité INSERM U55, Hôpital Saint-Antoine, 184, rue du, Faubourg Saint-Antoine, 75571 Paris Cédex 12, France

关键词: Enteroglucagon;    Proglucagon 78–107;    cyclic AMP;    (Gastric mucosa;    Fundic gland);   

DOI  :  10.1016/0014-5793(88)80297-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We tested the truncated 7–37 glucagon-like peptide 1 (TGLP-1), a naturally occurring porcine intestinal peptide, and other members of the glucagon family, including pancreatic glucagon (G-29), GLP-1 and GLP-2 for their ability to activate the cAMP generating system in rat gastric glands and HGT-1 human gastric cancer cells. In rat fundic glands, TGLP-1 was about 100 times more potent (EC₅₀ = 2.8 × 10⁻⁹M) than GLP-1 of G-29, and 10 times more potent than G-29 in the HGT-1 cell line. Our results support the notion that TGLP-1 plays a direct role in the regulation of acid secretion in rat and human gastric mucosa.

【 授权许可】

Unknown