The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible

FEBS Letters

Lambooy, Peter K.²  Evans, John A.²  Carlier, Marie-France²  Pantaloni, Dominique²  Webb, Martin R.¹  Korn, Edward D.² 

[1] National Institute for Medical Research, Mill Hill, London NW 71AA, England;Laboratoire d'Enzymologie, CNRS, Gif-sur-Yvette, France, Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

关键词: Actin;    Polymerization;    ATP hydrolysis;   

DOI  :  10.1016/0014-5793(88)81264-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin → F-ADP-P_i-actin.

【 授权许可】

Unknown