Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers

FEBS Letters

Patel, Harish M.¹  Wild, Arthur E.² 

[1] Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, England;Department of Biology, Univeristy of Southampton, Medical and Biological Sciences Building, Bassett Crescent East, Southampton SO9 3TU, England

关键词: Liposome;    Epithelium;    Transcytosis;    Immunoglobulin G;   

DOI  :  10.1016/0014-5793(88)80108-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Drug carriers such as liposomes are not readily transported across cellular barriers that constitute epithelia. However, certain epithelia (rabbit yolk sac endoderm and enterocytes of suckling rat gut proximal small intestine) are well known to transcytose maternal IgG by Fc receptor-mediated endocytic events. We have shown that coating liposomes with appropriate IgG enhances their transport across these epithelia, as measured both by radioactivity indicative of liposomal membrane or entrapped ¹²⁵I-PVP and [³H]inulin, and by the hypoglycemic effect of entrapped insulin. It is suggested that these transported liposomes follow a pathway of transcytosis in clathrin-coated vesicles, thus escaping lysosomal degradation.

【 授权许可】

Unknown