FEBS Letters | |
Finger proteins and DNA‐specific recognition: Distinct patterns of conserved amino acids suggest different evolutionary modes | |
Vincent, Alain1  Payre, François1  | |
[1] Centre de Recherche de Biochimie et Génétique Cellulaires du CNRS, 118, route de Narbonne, 31062 Toulouse Cedex, France | |
关键词: Finger protein; DNA binding; TFIIIA; Zn2+ chelation; Transcription activator; TFIIIA; transcription factor A of polymerase III; ICR; internal control region; PrKC; protein kinase C; C; cysteine; F; phenylalanine; H; histidine; L; leucine; Y; tyrosine; X; any amino acid; GR; glucocorticoid receptor; ER; oestrogen receptor; PR; progesterone receptor; MR; mineralocorticoid receptor; UAS; upstream activation site; | |
DOI : 10.1016/0014-5793(88)80091-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Finger proteins, the first example of which was Xenopus TFIIIA, share Zn2+ finger-like folded domains capable of binding to nucleic acids. A large number of this type of protein have been characterised from diverse organisms, indicating a wide evolutionary spread of the DNA-binding fingers. At least two classes of finger proteins may be distinguished. Class I proteins contain variable numbers of the tandemly repeating TFIIIA-like finger motif, (Y/F-X-C-X2–4-C-X3-F-X5-L-X2-H-X3-H). Class II finger proteins display a single (C-X2-C-X13-C-X2-C) motif and a facultative second putative finger. The relation between the structure of finger proteins and their recognised DNA sequences is discussed.
【 授权许可】
Unknown
【 预 览 】
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RO201912020290783ZK.pdf | 534KB | download |