The primary structure of transcription factor TFIIIA has 12 consecutive repeats

FEBS Letters

Brown, Raymond S.¹  Argos, Patrick¹  Sander, Christian² 

[1] European Molecular Biology Laboratory, Postfach 10.2209, FRG;Department of Biophysics, Max-Planck-Institut für medizinische Forschung, D-6900 Heidelberg, FRG

关键词: Transcription factor;    TFIIIA;    Primary structural repeat;   

DOI  :  10.1016/0014-5793(85)80723-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Analysis of the amino acid sequence of transcription factor TFIIIA from Xenopuslaevis reveals the presence of 12 repeating structures, each about 30 residues in length. These segments have been aligned and their secondary structure predicted. The repeats each contain two invariant cysteines and two invariant histidines, perhaps to coordinate a zinc cation. Possible nucleic acid interaction modes are discussed.

【 授权许可】

Unknown