C‐fos gene activation in murine thymocytes by a mechanism independent of protein kinase C or a Ca2+ signal

FEBS Letters

Metcalfe, James C.²  Moore, John P.¹  Menzel, Garry E.²  Hesketh, T.Robin² 

[1] Department of Veterinary Pathology, Veterinary School, Bearsden Road, Bearsden, Glasgow G61 1QH, Scotland;Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England

关键词: C-fos gene;    Signal transduction;    Ionic signal;    Protein kinase C;    Gene activation;    (Lymphocyte);   

DOI  :  10.1016/0014-5793(88)81356-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The accumulation of c-fos mRNA in mouse thymocytes was compared when the cells were stimulated by concanavalin A (Con A), the Ca²⁺ ionophore A23187 or the phorbol ester, TPA, either separately or by combinations of these mitogens. The c-fos response to mitogenic concentrations of Con A could not be attributed either to the rise in [Ca²⁺]_i it induces or to activation of protein kinase C. Thus, although Con A causes the breakdown of phosphatidylinositol 4,5-bisphosphate in these cells, neither of the signals which can be generated by this response was responsible for the activation of the c-fos gene by Con A. This implies that some other unidentified signal generated by Con A activates the c-fos gene.

【 授权许可】

Unknown