Phospholipid uptake by Plasmodium knowlesi infected erythrocytes

FEBS Letters

Roelofsen, B.²  Ancelin, M.L.¹  Moll, G.N.²  Op den Kamp, J.A.F.²  Vial, H.J.¹  van Deenen, L.L.M.² 

[1] CNRS UA 530, INSERM U 58, 60 Rue de Navacelles, 34100 Montpellier, France;Department of Biochemistry, Padualaan 8, 3584 CH Utrecht, The Netherlands

关键词: Malaria;    Phospholipid transfer protein;    Phospholipid turnover;    (Plasmodium knowlesi);   

DOI  :  10.1016/0014-5793(88)80765-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The uptake of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS) in Plasmodium knowlesi infected erythrocytes has been studied. Whereas uptake of phospholipids, in the absence of phospholipid transfer proteins, is negligible in control cells, the infected cells can incorporate considerable amounts of added phospholipids. The uptake is enhanced by the presence of lipid transfer proteins. Doubly labeled [³H]oleate, [¹⁴C]choline) PC does not undergo any appreciable remodelling following uptake, which strongly suggests that plasma PC is used as such for the biogenesis of the parasite membranes. Transport of extracellularly offered PS and PE towards the intraerythrocytic parasite and utilization of these lipids by the parasite are confirmed by the observation that these lipids are converted into respectively PE and PC. The extent and rate of these conversions depend on the way the phospholipids are introduced into the infected cells.

【 授权许可】

Unknown