Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Cardiovascular Diabetology

Original Investigation

Natália B Panzoldo¹  Eliana C de Faria¹  Vanessa S Zago¹  Eliane S Parra¹  Eder CR Quintão²  Camila C Leança²  Marisa Passarelli²  Valéria S Nunes²  Patrícia M Cazita²  Edna R Nakandakare²  Matti Jauhiainen³ 

[1] Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, P.O. Box 6111, CEP 13083-970, Campinas, SP, Brazil;Lipids Laboratory (LIM-10), Endocrinology and Metabolism Division of Hospital das Clinicas, Faculty of Medical Sciences, University of Sao Paulo, Av. Dr. Arnaldo, 455 - room 3305, CEP 01246-00, Sao Paulo, Brazil;Public Health Genomics Research Unit, National Institute for Health and Welfare, Helsinki, Finland;

关键词: Insulin resistance;    HDL-C concentration;    Lipoprotein lipases;    Lecithin cholesterol acyl transferase;    Pre-beta1 HDL;    Plasma cholesterol metabolism markers;    Cholesteryl ester transfer protein;    Phospholipid transfer protein;   

DOI  :  10.1186/1475-2840-12-173

 received in 2013-08-27, accepted in 2013-11-07,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundWe have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects.MethodsWe have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption.ResultsIn the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities.ConclusionsThese findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.

【 授权许可】

Unknown   
© Leança et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.