VLDL apoprotein secretion and apo‐B mRNA level in primary culture of cholesterol‐loaded rabbit hepatocytes

FEBS Letters

Berestetskaya, Yu.V.¹  Kosykh, V.A.¹  Podres, E.A.¹  Smirnov, V.N.¹  Repin, V.S.¹  Surguchov, A.P.¹  Novikov, D.K.¹  Sudarickov, A.B.¹ 

[1] USSR Cardiology Research Center, Academy of Medical Sciences, Moscow 121552, USSR

关键词: β-VLDL;    Cholesterol;    VLDL secretion;    Apolipoprotein B;    mRNA;    (Rabbit hepatocyte);    β-VLDL;    beta very low density lipoproteins;    apo;    apoprotein;    CH;    cholesterol;    ECH;    cholesterol esters;   

DOI  :  10.1016/0014-5793(88)80395-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Incubation of cultured rabbit hepatocytes with β very low density lipoproteins (β-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that β-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.

【 授权许可】

Unknown