Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

FEBS Letters

Inoue, Akihiro²  Itoh, Yasuaki¹  Onda, Haruo¹  Mitsui, Youji³  Ishida, Norio³  Kimura, Chiharu¹  Masaki, Tomoh²  Ohkubo, Shoichi¹  Kosaka, Takuo¹  Yanagisawa, Masashi²  Fujino, Masahiko¹ 

[1] Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan;Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan;Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan

关键词: Endothelin;    cDNA cloning;    Vasoconstrictor peptide;    Peptide processing;    Cardiovascular physiology;    (Endothelium);   

DOI  :  10.1016/0014-5793(88)80867-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

【 授权许可】

Unknown