The amino acid substitutions of human α1‐antitrypsin M3, X and Z

FEBS Letters

Jeppsson, Jan-Olof¹  Laurell, Carl-Bertil¹ 

[1] Department of Clinical Chemistry, Malmö General Hospital, University of Lund, S-214 01 Malmö, Sweden

关键词: α-1-Antitrypsin;    Genetic variant;    Amino acid sequence;    Peptide mapping;   

DOI  :  10.1016/0014-5793(88)80843-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

α₁-Antitrypsin has been isolated from individuals with inherited genetic variants M₃, X and Z. A fragmentation and peptide mapping system is described which together with amino acid and sequence analyses revealed the substitutions in M₃ at 376 of Glu to Asp, in X at 204 of Glu to Lys and in the physiologically innocent Z a mutation at 213 of Val to Ala. The latter represents a second amino acid substitution in the Z protein.

【 授权许可】

Unknown