Heparin inhibits IP3‐induced Ca2+ release in permeabilized pancreatic β‐cells

FEBS Letters

Zwiller, Jean¹  Berggren, Per-Olof²  Nilsson, Thomas²  Boynton, Alton L.¹ 

[1] Cancer Research Center of Hawaii, 1236 Lauhala St., Honolulu, Hawaii 96813, USA;Department of Medical Cell Biology, University of Uppsala, Biomedicum, Box 571, S-751 23 Uppsala, Sweden

关键词: Ca2 release;    Inositol 1;    4;    5-trisphosphate;    Inositol 1;    3;    4;    5-tetrakisphosphate;    Heparin;    (Permeabilized pancreatic β-cell);   

DOI  :  10.1016/0014-5793(88)80829-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Heparin was found to inhibit the Ca²⁺ release induced by inositol 1,4,5-trisphosphate (IP₃) in permeabilized pancreatic β-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca²⁺ uptake into the IP₃-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP₃ mobilizes Ca²⁺.

【 授权许可】

Unknown