期刊论文详细信息
FEBS Letters | |
Heparin inhibits IP3‐induced Ca2+ release in permeabilized pancreatic β‐cells | |
Zwiller, Jean1  Berggren, Per-Olof2  Nilsson, Thomas2  Boynton, Alton L.1  | |
[1] Cancer Research Center of Hawaii, 1236 Lauhala St., Honolulu, Hawaii 96813, USA;Department of Medical Cell Biology, University of Uppsala, Biomedicum, Box 571, S-751 23 Uppsala, Sweden | |
关键词: Ca2 release; Inositol 1; 4; 5-trisphosphate; Inositol 1; 3; 4; 5-tetrakisphosphate; Heparin; (Permeabilized pancreatic β-cell); | |
DOI : 10.1016/0014-5793(88)80829-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic β-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.
【 授权许可】
Unknown
【 预 览 】
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RO201912020290322ZK.pdf | 210KB | download |