Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter‐α‐trypsin inhibitor complex

FEBS Letters

Gebhard, Wolfgang¹  Schreitmüller, Thomas¹  Wachter, Elmar³  Hochstrasser, Karl² 

[1] Abteilung für Klinische Chemie und Klinische Biochemie in der Chirurgischen Klinik Innenstadt der Universität München, Nußbaumstr. 20, D-8000 München 2, FRG;Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke der Universität München, Klinikum Großhadern, Marchioninistr. 15, D-8000 München 70, FRG;Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, Goethestr. 33, D-8000 München 2, FRG

关键词: Proteinase inhibitor;    Inter-α-trypsin inhibitor;    Propeptide;    Posttranslational processing;    (Human serum);   

DOI  :  10.1016/0014-5793(88)80798-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Inter-α-trypsin inhibitor is composed of three distinct protein components. These protein components stem from independently encoded and proteolytically processed precursor proteins. Only the structure of the protein component responsible for the inhibitory activity has been established so far. We now present the complete amino acid sequence of the precursor of the second protein component derived from cloned cDNA. The precursor molecule includes both a signal peptide and a propeptide sequence and seems to be further processed prior to the assembly of the inter-α-trypsin inhibitor complex.

【 授权许可】

Unknown