cDNA and deduced amino acid sequence of human PK‐120, a plasma kallikrein‐sensitive glycoprotein

FEBS Letters

关键词: cDNA cloning;    Plasma kallikrein;    Plasma glycoprotein;    Bradykinin;    Inter-α-trypsin inhibitor;    Hyaluronic acid;    Human;    PK;    plasma kallikrein;    ITI;    inter-α-trypsin inhibitor;    HC;    heavy chain of the ITI superfamily;    PCR;    polymerase chain reaction;    HA;    hyaluronic acid;   

DOI  :  10.1016/0014-5793(94)01364-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-α-trypsin inhibitor (ITI) superfamily.

【 授权许可】

Unknown