Carbohydrate as covalent crosslink in human inter‐α‐trypsin inhibitor: A novel plasma protein structure

FEBS Letters

Faarvang, Karen L.¹  Ploug, Michael²  Jessen, Torben E.³ 

[1] Department of Rheumatology, Graasten Gigthospital, DK-6300 Graasten and Department of Internal Medicine, Holbaek Central Hospital, DK-4300 Holbaek, Denmark;Institute of Biochemical Genetics, University of Copenhagen, Ø Farimagsgade 2A, DK-1353 Copenhagen K, Denmark;Department of Clinical Chemistry, Holbaek Central Hospital DK-4300 Holbaek, Denmark

关键词: Inter-α-trypsin inhibitor;    Carbohydrate;    Chondroitin sulfate;    Crosslink;    Primary structure;    Polypeptide chain;   

DOI  :  10.1016/0014-5793(88)80670-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The primary structure of inter-α-trypsin inhibitor is partially elucidated, but controversy about the construction of the polypeptide backbone still exists. We present evidence suggesting that inter-α-trypsin inhibitor represents a novel plasma protein structure with two separate polypeptide chains covalently crosslinked only by carbohydrate (chondroitin sulphate)

【 授权许可】

Unknown