5‐Aminolevulinic acid formation from glutamate via the C5 pathway in Clostridium thermoaceticum

FEBS Letters

Stolowich, N.J.¹  Oh-hama, T.¹  Scott, A.I.¹ 

[1] Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, TX 77843, USA

关键词: 5-Aminolevulinic acid synthesis;    C5 pathway;    Corrinoid synthesis;    (Clostridium thermoaceticum);    ALA;    5-aminolevulinic acid;    RNase;    ribonuclease;    Tricine;    N-[2-hydroxy-1;    1-bis(hydroxymethyl)ethyl]glycine;   

DOI  :  10.1016/0014-5793(88)80591-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cell-free extract of the anaerobic eubacterium, Clostridium thermoaceticum, catalyses the synthesis of 5-aminolevulinic acid (ALA) from glutamate via the C₅ pathway. The enzyme reaction resembles that of higher plants and algae in cofactor requirements and sensitivity to ribonuclease. From the phylogenetic distribution it is proposed that the C₅ pathway evolved earlier than the ALA synthase pathway.

【 授权许可】

Unknown