cDNA clones completing the nucleotide and derived amino acid sequence of the alpha 1 chain of basement membrane (type IV) collagen from mouse

FEBS Letters

Vogeli, Gabriel¹  Theriault, Nicole²  Wood, Linda¹ 

[1] Molecular Biology Research, The Upjohn Company, Kalamazoo, MI 49001, USA;Biopolymer Chemistry Research, The Upjohn Company, Kalamazoo, MI 49001, USA

关键词: Basement membrane;    Signal peptide;    7 S region;    NC2 domain;    Helical domain;    Helical interruption;    aa;    amino acid(s);    cDNA;    DNA complementary to mRNA;    nt;    nucleotide(s);   

DOI  :  10.1016/0014-5793(88)81402-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Six cDNA clones add 3549 nucleotides to the DNA sequence of the alpha 1 chain of basement membrane (type IV) collagen. Thus the complete nucleotide and derived amino acid sequence of the alpha 1 type IV collagen with 5007 nucleotides coding for 1669 amino acids with a calculated M _r of 160 827 is known. The six cDNA clones cover the putative N-terminal signal peptide, the 7 S region and two thirds of the helical region extending into the previously published murine nucleotide sequence [(1986) Gene 43, 301]. The protein sequence for 289 amino acids of the helical region adjacent to the 7 S region has not previously been published for any species.

【 授权许可】

Unknown