Identification of putative internalization signals in prion proteins

FEBS Letters

Kazim, A.Latif¹ 

[1] Department of Molecular Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

关键词: Prion protein;    Endocytosis;    Signal peptide;   

DOI  :  10.1016/0014-5793(93)80285-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Prion proteins were found to contain regions in their cytoplasmic domains that have significant structural homologies to molecular trafficking signals for internalization of membrane proteins. These regions may facilitate the endocytosis of prion proteins, which appears to be a first step in their conversion to the abnormal, amyloidogenic form.

【 授权许可】

Unknown