Spontaneous conversion of PrPC to PrPSc

FEBS Letters

Sulkowski, Eugene¹ 

[1] Roswell Park Cancer Institute, Buffalo, NY 14263, USA

关键词: Prion protein;    Transition metal;    Conformational isoform;    Conversion of PrPC to PrPSc;    Prion disease;   

DOI  :  10.1016/0014-5793(92)80750-B

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Octa-repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrP^C (cellular) isoform into PrP^Sc (scrapie) isoform may be triggered by the coordination of these metals.

【 授权许可】

Unknown