The structure of procalcitonin of the salmon as deduced from its cDNA sequence

FEBS Letters

Besemer, J.¹  Hofer, E.¹  Seifert, J.-M.¹  Brunowsky, W.¹  Pöschl, E.¹  Lindley, I.¹ 

[1] Sandoz Forschungsinstitut, Brunner Straße 59, A-1235 Wien, Austria

关键词: Calcitonin;    cDNA cloning;    Nucleotide sequence;    Amino acid sequence;    (Salmon);   

DOI  :  10.1016/0014-5793(87)80558-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oligonucleotide probes based on the known amino acid sequence of salmon calcitonin were used to screen a cDNA library obtained from ultimobranchial glands of salmon for clones encoding salmon calcitonin. From the cDNA sequence of strongly hybridizing clones the complete primary structure of the calcitonin precursor could be deduced. Its overall structure is identical with the structures of procalcitonins from other vertebrates and has the highest homology with the chicken precursor.

【 授权许可】

Unknown