A 63 kDa protein is secreted from BALB/c‐3T3 cells entering the G1 phase from the G0 state

FEBS Letters

Tominaga, Shin-ichi¹ 

[1] Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-ku, Tokyo 105, Japan

关键词: Cell cycle;    Cell growth;    Protein secretion;    Interferon;    IFN;    interferon;    DME;    Dulbecco's modified Eagle's medium;    MEM;    minimum Eagle's medium;    PDGF;    platelet-derived growth factor;   

DOI  :  10.1016/0014-5793(87)80549-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A 63 kDa protein is detectable in the culture fluid of mouse BALB/c-3T3 cells traversing from the G₀, state to the G₁ phase, whereas it is undetectable in the culture fluid of quiescent or growing BALB/c-3T3 cells. Secretion of the protein is maximal at 10 h after serum addition. G₀-specific ts mutant cells (rat tsJT60) also secrete the 63 kDa protein only when the quiescent cells are stimulated by serum addition at permissive temperature. These facts indicate that the 63 kDa protein is secreted only from cells traversing from the G₀, state to the G₁, phase.

【 授权许可】

Unknown