Thyroid hormone uptake into the cell and its subsequent localisation to the mitochondria

FEBS Letters

Hafner, Roderick P.¹ 

[1] Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England

关键词: Thyroid hormone;    Active transport;    Mitochondria;    Receptor;    Adenine nucleotide translocator;    T3;    3;    5;    3′-triiodo-L-thyronine;    T4;    L-thyroxine;   

DOI  :  10.1016/0014-5793(87)80464-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nature of thyroid hormone uptake into the cell and the possible involvement of the serum carrier proteins and receptor-mediated endocytosis in this process are reviewed. The evidence that there is a specific thyroid hormone-binding receptor in the inner mitochondrial membrane and the relation of this to the adenine nucleotide translocator is discussed. Direct effects of thyroid hormone on mitochondrial function that might be mediated by such a receptor are also considered.

【 授权许可】

Unknown