A small, discrete acyl carrier protein is involved in de novo fatty acid biosynthesis in Streptomyces erythraeus

FEBS Letters

Hale, Richard S.¹  Jordan, Keith N.¹  Leadlay, Peter F.¹ 

[1] Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB21 QW, England

关键词: Fatty acid synthase;    Acyl carrier protein;    (Streptomycetes);   

DOI  :  10.1016/0014-5793(87)80436-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A heat-stable factor, required for de novo synthesis of fatty acids in the erythromycin-producing organism Streptomyces erythraeus, has been purified to homogeneity and identified as an acyl carrier protein (ACP). We conclude that, contrary to previous belief, fatty acid synthase in S. erythraeus more closely resembles the dissociable complex of E. coli than the tightly associated, multifunctional enzyme complex found in the related actinomycete Mycobacterium smegmatis.

【 授权许可】

Unknown