Effect of γ‐butyrolactone derivative on an artificial membrane

FEBS Letters

Grigoriev, P.A.²  Schlegel, R.¹  Römer, W.¹  Gräfe, U.¹ 

[1] Central Institute of Microbiology and Experimental Therapy, GDR Academy of Sciences, PO Box 73, DDR-6900 Jena, GDR;Institute of Biophysics, USSR Academy of Sciences, Pushchino na Oke 142292, USSR

关键词: Cytodifferentiation;    (Streptomycetes);    Autoregulator;    γ-Butyrolactone derivative;    Membrane effect;    Passive ion flux;   

DOI  :  10.1016/0014-5793(86)81398-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

trans-2-(6'Methylheptanol-1'-yl)-3-hydroxymethyl-4-butanolide(II) was shown to increase the passive flux of cations such as Co²⁺ through a black lipid membrane made from ox brain phospholipids. This membranotropic effect appears to be involved in the activity of II towards blocked mutants of streptomycetes as an autoregulator of cytodifferentiation.

【 授权许可】

Unknown