Receptor‐phosphoinositidase C coupling Multiple G‐proteins?

FEBS Letters

Lo, William W.Y.¹  Hughes, John¹ 

[1] Parke-Davis Research Unit, Addenbrookes Hospital Site, Hills Road, Cambridge CB2 2QB, England

关键词: G-protein;    Phosphoinositidase C;    Phosphoinositide;    Pertussis toxin;    Cholera toxin;    ras ocogene;   

DOI  :  10.1016/0014-5793(87)80410-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent evidence has suggested that receptor-mediated phosphoinositide turnover, like that of the adenylate cyclase cAMP pathway, is regulated by guanine nucleotides. It is likely that one or more guanine nucleotide-binding proteins (G-proteins) couple calcium-mobilizing receptors to the activation of phosphoinositidase C. Recent studies utilizing various bacterial toxins have strongly suggested the presence of multiple G-proteins in the regulation of receptor-phosphoinositidase C coupling in a variety of cell types.

【 授权许可】

Unknown