Characterization of glucacon receptors in Golgi fractions of fetal rat liver

FEBS Letters

Alvarez, Elvira¹  de Diego, Juana G.¹  Blázquez, Enrique¹ 

[1] Departamento de Bioquímica, Facultad de Medicina, 37007 Salamanca, Spain

关键词: Glucagon receptor;    Golgi fraction;    Fetus;    (Wistar rat);   

DOI  :  10.1016/0014-5793(87)80381-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present study was designed to determine if Golgi fractions from fetal rat liver contain glucagon receptors and to characterize the properties of such receptors. Purification patterns of liver plasma membranes and Golgi fractions from fetal and adult rats were similar, as verified by morphological and biochemical approaches. Glucagon binding was greater in plasma membranes of adult than fetal rats, while in Golgi fractions glucagon binding was similar in both groups. The modifications in glucagon binding reflect changes in glucagon receptors. Glucagon association and glucagon receptor inactivation by liver membranes were similar in the two groups of animals, while glucagon degradation was lower in fetal than in adult rats.

【 授权许可】

Unknown