A new redox loop formality involving metal‐catalysed hydroxide‐ion translocation A hypothetical Cu loop mechanism for cytochrome oxidase

FEBS Letters

Mitchell, Peter¹ 

[1] Glynn Research Institute, Bodmin PL30 4AU, England

关键词: Cytochrome oxidase;    Cu center;    Hydroxidemotive redox loop;    Cu loop mechanism;    Chemiosmotic coupling;    Hydroxide-ion translocation;    Q;    ubiquinone or plastoquinone;    QH2 ubiquinol or plastoquinol;    CuA;    CuB and Cux;    electron-transferring copper centres in cytochrome oxidase;    ENDOR;    electron nuclear double resonance;   

DOI  :  10.1016/0014-5793(87)80378-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new hypothetical type of redox loop is described, which translocates hydroxide ions instead of protons. Conventional protonmotive redox loops use carriers of protons with electrons (e.g. QH₂/Q systems) to couple electron transfer to the translocation of protons. The putative hydroxidemotive redox loop uses carriers of hydroxide ions against electrons (e.g. transition-metal centres) to couple electron transfer to the translocation of hydroxide ions. This simple idea leads to the proposal of a hydroxidemotive Cu loop mechanism that may possibly be applicable to the Cu_A or Cu_B centre of cytochrome oxidase, and might thus account for the coupling of electron transfer to net proton translocation in that osmoenzyme.

【 授权许可】

Unknown