FEBS Letters | |
Strategy of research on the chemiosmotic mechanism of cytochrome oxidase | |
Mitchell, Peter1  | |
[1] Glynn Research Institute, Bodmin, Cornwall PL30 4AU, England | |
关键词: Chemiosmotic strategy; Redox loop concept; Cu center; Cu loop mechanism; Hydroxidemotive loop; Oxidemotive loop; | |
DOI : 10.1016/0014-5793(88)80746-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In recent papers on protonmotive redox mechanisms in cytochrome oxidase in [(1987) FEBS Lett. 222, 235–245] and [Glynn Biological Research Reports (1987) 3, 1–7], I have suggested that a copper centre may enable the H2O/OH or H2O/O couple to act as the hydrogen-carrying arm of a redox loop by means of a (CuOH2)+/(CuOH)+ or (CuOH2)+/ (CuO)+ system at the centre. I here explain that critical comments by Malmström [(1988) FEBS Lett. 231, 268–269] on the first of these papers, which might also be levelled at the second, depend on a misunderstanding. I also respond to Malmström's comment about testing conformationally coupled proton-pump mechanisms.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020290483ZK.pdf | 169KB | download |