期刊论文详细信息
FEBS Letters
Strategy of research on the chemiosmotic mechanism of cytochrome oxidase
Mitchell, Peter1 
[1] Glynn Research Institute, Bodmin, Cornwall PL30 4AU, England
关键词: Chemiosmotic strategy;    Redox loop concept;    Cu center;    Cu loop mechanism;    Hydroxidemotive loop;    Oxidemotive loop;   
DOI  :  10.1016/0014-5793(88)80746-4
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

In recent papers on protonmotive redox mechanisms in cytochrome oxidase in [(1987) FEBS Lett. 222, 235–245] and [Glynn Biological Research Reports (1987) 3, 1–7], I have suggested that a copper centre may enable the H2O/OH or H2O/O couple to act as the hydrogen-carrying arm of a redox loop by means of a (CuOH2)+/(CuOH)+ or (CuOH2)+/ (CuO)+ system at the centre. I here explain that critical comments by Malmström [(1988) FEBS Lett. 231, 268–269] on the first of these papers, which might also be levelled at the second, depend on a misunderstanding. I also respond to Malmström's comment about testing conformationally coupled proton-pump mechanisms.

【 授权许可】

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