Maintenance of membrane phospholipid asymmetry Lipid‐cytoskeletal interactions or lipid pump?

FEBS Letters

Antia, Rustom¹  Schlegel, Robert A.³  Williamson, Patrick² 

[1] Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003 USA;Department of Biology, Amherst College, Amherst, MA 01002, USA;Department of Molecular and Cell Biology, The Pennsylvania State University, University Park, PA 16802, USA

关键词: Phospholipid asymmetry;    Lipid flip/flop;    Lipid pump;    Spectrin;    Cellular adherence;    (Erythrocyte;    Blood cell);   

DOI  :  10.1016/0014-5793(87)80243-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two models for the mechanism of maintenance of lipid asymmetry in erythrocytes are considered: binding of internal lipids to cytoskeletal proteins, and pumping of internal lipids from the outside to the inside of the cell. Analysis of the kinetics of lipid internalization suggests that the first model is more likely, and that the apparent pumping of lipids represents the activity of an ATP-dependent lipid flip/flop catalyst.

【 授权许可】

Unknown