Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins

FEBS Letters

Barton, Geoffrey J.³  Coates, Anthony R.M.²  Zvelebil, Marketa J.³  Sternberg, Michael J.E.³  Cookson, John¹ 

[1] Hill Computer Centre London Hospital Medical College, Turner Street, London E1 2AD, England;Department of Medical Microbiology, London Hospital Medical College, Turner Street, London E1 2AD, England;Laboratory of Molecular Biology, Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, England

关键词: AIDS;    Human immunodeficiency virus;    Peptide vaccine;    Epitope;    Secondary structure prediction;   

DOI  :  10.1016/0014-5793(87)81052-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition to the env gene envelope glycoproteins being actively studied. The predictions of B- and T-epitopes are refined by consideration of secondary structure prediction and inter-isolate sequence variability to suggest peptides from env, gag and pol that would be the best vaccine candidates.

【 授权许可】

Unknown