Molecular evolution of the calmodulin gene

FEBS Letters

Nojima, Hiroshi¹ 

[1] Department of Pharmacology, Jichi Medical School Minamikawachi-machi, Tochigi-ken 329-04, Japan

关键词: Calmodulin;    Calmodulin gene;    Nucleotide sequence;    Sequence homology;    Evolution;   

DOI  :  10.1016/0014-5793(87)80661-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

On the basis of the intron/exon organization and the intramolecular homology of DNA sequences, I propose a novel model for genesis of the calmodulin gene. A primordial calmodulin gene consisting of 51 base pairs (17 amino acids) was subjected to three-fold duplication to create modern calmodulin with four calcium-binding subdomains. The model elucidates the seemingly enigmatic positions of splice junctions observed in calmodulin genes.

【 授权许可】

Unknown