Experimental and theoretical study of gramicidin P, an analog of gramicidin A with a methylamine C‐terminal

FEBS Letters

Pullman, A.¹  Trudelle, Y.³  Daumas, P.²  Etchebest, C.¹  Heitz, F.² 

[1] Laboratoire de Biochimie Théorique (UA77), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France;Laboratoire de Physicochimie des Systèmes Polyphasés (UA330), Route de Mende, B4033 Montpellier Cédex, France;Centre de Biophysique Moléculaire CNRS, 1A avenue de la Recherche Scientifique, 45071 Orléans Cédex, France

关键词: Gramicidin P;    Energy profile;    Conductance;    Gramicidin A analog;   

DOI  :  10.1016/0014-5793(87)80747-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Gramicidin P (a gramicidin A in which the ethanolamine C-terminus is replaced by methylamine) was synthesized and shown to have the same single-channel conductance behavior as gramicidin A. The results are discussed in connection with the energy profile computed in the presence of water in comparison with the corresponding profile for gramicidin A.

【 授权许可】

Unknown