The gramicidin A channel

FEBS Letters

Pullman, Alberte¹  Etchebest, Catherine¹ 

[1] Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé du CNRS, 13 rue Pierre et Marie Curie, 75005 Paris, France

关键词: Gramicidin A;    Ethanolamine end;    Energy profile;    Sodium;    Single occupancy;    Theoretical computation;   

DOI  :  10.1016/0014-5793(84)81397-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The inclusion of the presence and flexibility of the CH₂CH₂OH end chain in the computation of the energy profile for single occupancy by Na⁺ of the gramicidin A channel modifies substantially the profile obtained without that chain. The binding site (deepest minimum) in the profile is situated at 10.5 Å from the center of the channel, in satisfactory agreement with the conclusions based on ¹³C-NMR studies. The existence of an external minimum at the mouth is confirmed.

【 授权许可】

Unknown