Assignment of resonances for ‘acute‐phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma

FEBS Letters

Sadler, P.J.¹  Brown, J.C.C.¹  Nicholson, J.K.¹  Bell, J.D.¹ 

[1] Department of Chemistry, Birkbeck College, Univerity of London, Malet Street, London WC1E 7HX, England

关键词: 1H-NMR;    Plasma;    Glycoprotein;    N-acetylated sugar;    Acute-phase protein;   

DOI  :  10.1016/0014-5793(87)80168-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Broad resonances at 2.04 and 2.08 ppm in 500 MHz Hahn spin-echo ¹H NMR spectra of human blood plasma are assigned to the N-acetyl groups of mobile carbohydrate side-chains (largely N-acetylglucosamine and N-acetylneuraminic acid) of glycoproteins such as α₁,-acid glycoprotein. Their intensities in spin-echo spectra correlate with clinical conditions in which an elevation of the level of ‘acute-phase’ glycoproteins is expected, and so may be of value in the study of certain diseases.

【 授权许可】

Unknown