NMR Detection of Isomers Arising from Restricted Rotation of the C-N Amide Bond of N-Formyl-o-toluidine and N,N’-bis-Formyl-o-tolidine

Molecules

Ramiro Quintanilla-Licea¹  Juan F. Colunga-Valladares¹  Adolfo Caballero-Quintero¹  Cristina Rodríguez-Padilla¹  Reyes Tamez-Guerra¹  Ricardo Gómez-Flores¹ 

[1] ¹Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Pedro de Alba s/n, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, México

关键词: Amide bond;    restricted rotation;    1H-NMR;    13C-NMR;    NOE;   

DOI  :  10.3390/70800662

来源: mdpi

【 摘 要 】

Full and unambiguous assignment of all ¹H- and ¹³C-NMR resonances of the isomers due to restricted C-N amide bond rotation of N-formyl-o-toluidine and N,N'-bis-formyl-o-tolidine in DMSO-d₆ is reported. The cis-isomer predominates in the equilibrium mixture of both compounds as 1D-NOE difference experiments show.

【 授权许可】

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