Fecal excretion of intestinal glycosphingolipids by newborns and young children

FEBS Letters

Watsfeldt, Peter³  Falk, Per³  Larson, Göran³  Leffler, Hakon²  Koprowski, Hilary¹ 

[1] The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104-4268, USA;LPPI, Box 29C, University of California, 401 Parnassus Avenue, San Francisco, USA;Department of Clinical Chemistry, Sahlgren's Hospital, University of Göteborg, S-413 45 Gothenburg, Sweden

关键词: Blood group;    Glycosphingolipid;    Bacterial receptor;    Weaning;    (Human meconium;    Feces);   

DOI  :  10.1016/0014-5793(87)80009-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glycosphingolipids were shown to persist in human fecal excretions from birth up 2 years of age. The pattern of glycosphingolipids was dependent on blood group and secretor status of the child and changed dramatically during the first months of life. Perinatally cerebroside, hematoside and blood group active fucolipids were dominating among fecal glycolipids. From the time of weaning lactosylceramide abruptly became and then persisted as a dominating glycolipid although cerebroside, complex gangliosides and blood group active fucolipids could still be detected in feces even at 2 years of age.

【 授权许可】

Unknown