The leader peptides from bacteriorhodopsin and halorhodopsin are potential membrane‐spanning amphipathic helices

FEBS Letters

von Heijne, Gunnar²  Segrest, Jere P.¹ 

[1] Departments of Pathology, Biochemistry and Medicine and Atherosclerosis Reserach Unit, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA;Research Group for Theoretical Biophysics, Royal Institute of Technology, S-100 44 Stockholm, Sweden

关键词: Bacteriorhodopsin;    Halorhodopsin;    Membrane protein;    Leader peptide;    Amphipathic helix;   

DOI  :  10.1016/0014-5793(87)81497-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We show that the N-terminal leader peptides from the bacterial membrane proteins bacteriorhodopsin and halorhodopsin can be expected to form amphipathic α-helices with a highly hydrophobic nonpolar face and a narrow, negatively charged polar face. This finding is discussed in terms of a model for the integration of these proteins into the bacterial membrane.

【 授权许可】

Unknown