Interaction of synthetic analogs of distamycin with DNA

FEBS Letters

Ayyer, Jayalekshmy¹  Dasgupta, Dipak¹  Sasisekharan, V.¹  Parrack, Pradipkumar¹ 

[1] Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

关键词: Drug-DNA interaction;    Distamycin analog;    AT-base specificity;    Minor groove binding;    poly(dA-dT);    alternating copolymer poly(dA-dT)·poly (dA-dT);    poly(dG-dC);    alternating copolymer poly(dG-dC)·poly(dG-dC);   

DOI  :  10.1016/0014-5793(87)81364-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interaction of two synthetic analogs of distamycin (Dst), PPA and PAP, containing a saturated β-alanine moiety replacing one N-methylpyrrole ring, with different polynucleotides and natural DNAs were studied using UV and CD spectroscopy. The results indicate that, similar to Dst, these analogs bind to DNA via the minor groove with a specificity towards AT-base pairs. It may be proposed that pyrrole chromophores in Dst probably do not play a role in the AT-base selectivity exhibited by Dst.

【 授权许可】

Unknown