Interaction of myelin basic protein with the different components of the ATP, Mg‐dependent protein phosphatase system

FEBS Letters

Vanden Abeele, Carline¹  Merlevede, Wilfried¹  Vandenheede, Jackie R.¹  Van Lint, Johan¹ 

[1] Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

关键词: Myelin basic protein;    ATP;    Mg dependence;    Protein phosphatase;    Protein kinase FA;    Modulator protein;   

DOI  :  10.1016/0014-5793(87)81434-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Myelin basic protein (MBP) reduces the amount of phosphatase activity produced in the kinase F_A-mediated activation of the ATP,Mg-dependent phosphatase. MBP was shown not only to inhibit the activated enzyme, but also to impair the kinase F_A-mediated activation of the inactive phosphatase. In addition MBP prevents the time-dependent inactivation of the catalytic subunit by the modulator protein. These observations point to a regulatory role for MBP in the reversible activation of the ATP, Mg-dependent protein phosphatase by kinase F_A.

【 授权许可】

Unknown