Scorpion venom inhibits selectively Ca2+‐activated K+ channels in situ

FEBS Letters

Simonneau, Michel¹  Leneveu, Estelle¹ 

[1] Laboratoire de Neurobiologie Cellulaire et Moléculaire, Centre National de la Recherche Scientifique, 91190 Gif-sur- Yvette, France

关键词: Leiurus quinquestriatus;    Ion channel;    Ca2+ activation;    K+ channel;    Patch clamp;   

DOI  :  10.1016/0014-5793(86)81104-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using patch-clamp techniques, a study was made of the component of Leiurus quinquestriatus scorpion venom which caused a blockade of one class of membrane potassium channels, the calcium activated potassium (BK) channels. This blockade was obtained on channels in their native lipidic environment and was specific for this class of channels as other types of potassium channels were not affected by this venom.

【 授权许可】

Unknown