A large conductance, voltage‐ and calcium‐activated K+ channel in the basolateral membrane of rat enterocytes

FEBS Letters

Gallacher, D.V.¹  Lee, J.A.C.²  Morris, A.P.¹ 

[1] MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, PO Box 147, Liverpool L69 3BX England;Zoology Department, University of Liverpool, Liverpool L69 3BX, England

关键词: K+ channel;    Enterocyte;    Patch-clamp;    Voltage activation;    Ca2+ activation;    Ba2+;   

DOI  :  10.1016/0014-5793(86)81346-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The patch-clamp technique was employed to record single channel currents in patches of basolateral membrane from enterocytes isolated from rat small intestine. We demonstrate the presence of a large conductance (250 pS), voltage- and calcium-activated, the maxi. K⁺ channel in this membrane. Currents in this K⁺ channel were blocked by the application of barium (5 mM) to the extracellular membrane face.

【 授权许可】

Unknown